Chroman derivatives as anti-oxidants

Details Chroman derivatives as anti-oxidants Chroman derivatives as anti-oxidants

1997-01-24

1998-05-05

Northington-Davis, Zinna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549407, 544151, 5142335, C07D31104, A61K 3135

Patent

active

057475288

ABSTRACT:
Chroman derivatives of Formula I or a pharmaceutically acceptable salt thereof are inhibitors of VCAM-1 and ICAM-1 and are thus useful in the treatment of inflammation, atherosclerosis, restenosis, and immune disorders such as arthritis and transplant rejection ##STR1## wherein: R=Hydrogen or phenyl;

REFERENCES:
patent: 4360532 (1982-11-01), Sundeen
patent: 5015661 (1991-05-01), Walser
patent: 5055598 (1991-10-01), Ohuchida et al.
patent: 5132310 (1992-07-01), Walser
patent: 5169957 (1992-12-01), Ohuchida et al.
patent: 5260294 (1993-11-01), Walser
patent: 5266709 (1993-11-01), Ohuchida et al.
patent: 5374643 (1994-12-01), Atwal et al.
patent: 5380747 (1995-01-01), Medford et al.
patent: 5384414 (1995-01-01), Ohuchida et al.
patent: 5387596 (1995-02-01), Takebayashi et al.
patent: 5508450 (1996-04-01), Ohuchida et al.
Faruqi and DiCorleto, Br. Heart J., 1993, 69(Suppl.):s19-s29.
Ross Nature, 1993, 362:801-809.
Li et al., Arteriosclerosis Throm., 1993, 13(2):197-204.
O'Brien et al., J. Clin. Invest., 1993, 92:945-951.
Collins, Lab. Invest., 1993, 68(5):499-508.
Tanaka et al., Circulation, 1993, 88(4)Part 1:1788-1803.
Marui et al., J. Clin. Invest., 1993, 92:1866-1874.
Pelletier et al., J. Immunol., 1992, 149(7):2473-2481.
Pryor et al., J. Org. Chem., 1993, 58(13):3521-3532.
Yoshioka et al., J. Med. Chem., 1989, 32(2):421-428.

Affiliated with

Also associated with

Rating

Chroman derivatives as anti-oxidants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chroman derivatives as anti-oxidants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chroman derivatives as anti-oxidants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-55199