Certain 4-formamidothiazoles

Details Certain 4-formamidothiazoles Certain 4-formamidothiazoles

1978-05-15

1981-02-03

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424270, C07D27738

Patent

active

042490120

ABSTRACT:
The invention relates to the use of thiazoles in the treatment of ulcers and/or hypersecretion in mammals. The invention also provides in a preferred aspect a pharmaceutical composition for use in the treatment of ulcers or hypersecretion comprising a compound of formula I ##STR1## where R.sup.1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms (which may be substituted by chlorine), or cyclopropyl, R.sup.3 is hydrogen or COR.sup.4 where R.sup.4 is as defined for R and R and R.sup.4 may be the same or different and a pharmaceutically acceptable carrier.

REFERENCES:
patent: 3244723 (1966-04-01), Johnson et al.
patent: 3515538 (1975-06-01), Veno et al.
patent: 3686190 (1972-08-01), Malen et al.
patent: 3740409 (1973-06-01), Brenner et al.
patent: 3956494 (1976-05-01), Loev
patent: 4061637 (1977-12-01), Manghisi et al.

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