Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-02-12
1981-02-03
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424258, 546 18, 548309, A61K 31415, A61K 3147, C07D49510, C07D491107
Patent
active
042488826
ABSTRACT:
A series of amino-and alkylamino-substituted spirohydantoins and pharmaceutically acceptable salts thereof useful as inhibitors of the enzyme aldose reductase and as therapeutic agents for the treatment of chronic complications associated with diabetes are disclosed. Preferred compounds include 6-chloro-8-amino-spiro[4H-2,3-dihydro-1-benzopyran-4,4'-imidazolidine]-2', 5'-dione, the 6-fluoro and 8-methylamino- analogs thereof and the corresponding dihydrobenzothiopyran analogs of these compounds. The optical isomers of these compounds having the 4S-configuration are especially preferred.
REFERENCES:
patent: 3534037 (1970-10-01), Loev
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4117230 (1978-09-01), Sarges
patent: 4130714 (1978-12-01), Sarges
patent: 4176185 (1979-11-01), Schnur
patent: 4177282 (1979-12-01), Sarges
patent: 4181729 (1980-01-01), Sarges et al.
Sarges Reinhard
Schnur Rodney C.
Jiles Henry R.
Knuth Charles J.
Murphy Francis X.
Pfizer Inc.
Richardson Peter C.
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