3-Halo cephalosporins

Details 3-Halo cephalosporins 3-Halo cephalosporins

1980-07-02

1981-07-28

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, C07D50120

Patent

active

042811163

ABSTRACT:
7-Acylamido- and 7-amino-3-halo-3-cephem-4-carboxylic acids, esters and pharmaceutically-acceptable salts and esters thereof are new cephalosporin compounds provided by the reaction of a 7-acylamido-3-hydroxy-3-cephem-4-carboxylic acid ester or a 7-amino-3-hydroxy-3-cephem-4-carboxylic acid ester with an iodinating, fluorinating, chlorinating, or brominating reagent. For example, 7-amino-3-chloro-3-cephem-4-carboxylic acid and 7-phenoxyacetamido-3-chloro-3-cephem-4-carboxylic acid are provided. The 7-acylamido-3-halo cephalosporin acids and pharmaceutically acceptable salts and esters provided are valuable antibiotic compounds having desirable therapeutic properties.

REFERENCES:
patent: 3258461 (1966-06-01), Cocker et al.
patent: 3705897 (1972-12-01), Murphy
patent: 3925372 (1975-12-01), Chauvette
patent: 3926978 (1975-12-01), Koppel
patent: 3932398 (1976-01-01), Nudelman
patent: 3963712 (1976-06-01), Koyama et al.
patent: 4064343 (1977-12-01), Chauvette
patent: 4208515 (1980-06-01), Chauvette

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