Process for the production of 7-acylamidocephalosporins

Details Process for the production of 7-acylamidocephalosporins Process for the production of 7-acylamidocephalosporins

1974-11-29

1977-03-29

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50104

Patent

active

040148734

ABSTRACT:
New 7-diacylimido cephalosporins are produced by reacting 7-acylamido cephalosporins with an acylating agent in the presence of a silyl reagent. The 7-diacylimido cephalosporins are cleaved to produce cephalosporins containing a different acylamido moiety. Thus, the aminoadipoyl group of cephalosporins produced by fermentation is replaced by a different acyl group by the process of the present invention. The cephalosporins produced are antibiotics having enhanced activity against gram-negative and gram-positive pathogens.

REFERENCES:
patent: 3859282 (1975-01-01), Cheng et al.
patent: 3926954 (1975-12-01), Kiesewetter et al.
Karady et al., J. Am. Chem. Soc. 94(4), pp. 1410-1411, Feb. 23, 1972.
Abe et al., Chemical Abstracts, vols. 78, 27,925 c. (1973).

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