Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-10-02
1998-05-05
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 179, A61K 3170, C07H 1500
Patent
active
057474630
ABSTRACT:
There is provided a novel series of malonate derivatives of glycolipid compounds of the formula ##STR1## wherein R is an acyl residue of a fatty acid:
REFERENCES:
Hsu-Lin, S., et al., "A Platelet Membrane Protein Expressed during Platelet Activation and Secretion" J. Biol. Chem., 259/14, 9121-9126 (Jul. 1984).
Stenberg, P.E., et al., "A Platelet Alpha-Granule Membrane Protein (GMP-140) Is Expressed on the Plasma Membrane after Activation," J. Cell Biol., 101, 880-886 (Sep. 1985).
McEver, R.P., et al., "GMP-140, a Platelet Alpha-Granule Membrane Protein, Is Also Synthesized by Vascular Endothelial Cells and Is Localized in Weibel-Palade Bodies" J. Clin. Invest., 84, 92-99 (Jul. 1989).
Bonfanti, R., et al., "PADGEM (GMP 140) Is a component of Weibel-Palade Bodies of Human Endothelial Cells," Blood, 73, 1109-1112 (Apr. 1989).
Hattori, R., et al., "Complement Proteins C5b-9 Induces Secretion of High Molecular Weight Multimers of Endothelial von Willebrand Factor and Translocation of Granule Membrane Protein GMP-140 to the Cell Surface," J. Biol. Chem., 264, 9053-9060 (May 1989).
Patel, K.D., et al., "Oxygen Radicals Induce Human Endothelial Cells to Express GMP-140 and Bind Neutrophils," J. Cell Biol., 112, 749-759 (Feb. 1991).
Larsen, et al., "PADGEM-Dependent Adhesion of Platelets to Monocytes and Neutrophils is Mediated by a Lineage-Specific Carbohydrate, LNF III (CD15)," Cell, 63, 467-474 (Nov. 1990).
Erbe, et al., "Identification of an E-selectin Region Critical for Carbohydrate Recognition and Cell Adhesion," J. Cell Biol., 112, 749-759 (Oct. 1991).
Skinner, et al., "Characterization of Human Platelet GMP-140 as a Herparin-Binding Protein," Biochem. Biophys. Res. Commun., 164, 1373-1379 (Nov. 1989).
Skinner, et al., "GMP-140 Binding to Neutrophils is Inhibited by Sulfated Glycans," J. Biol. Chem., 266, 5371-5374 (Mar. 1991).
Aruffo, et al., "CD62/P-Selectin Recognition of Myeloid and Tumor Cell Sulfatides," Cell, 67, 35-44 (Oct. 1991).
Suzuki, et al., "Sulfated Glycolipids are Ligands for a Lymphocyte Homing Receptor, L-Selectin (LECAM-1), Binding Epitope in Sulfated Sugar Chain," Biochem. Biophys. Res. Commun., 190, 426-434 (Jan. 1993).
M.S. Mulligan, et al., "Protective Effects of Oligosaccharides in P-selectin-dependent Lung Inury," Nature, 364, 149-151 (Jul. 1993).
Marinier Anne
Martel Alain
Algieri Aldo A.
Bristol--Myers Squibb Company
Fonda Kathleen K.
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