Bovine pancreatic trypsin inhibitor derived inhibitors of factor

Details Bovine pancreatic trypsin inhibitor derived inhibitors of factor Bovine pancreatic trypsin inhibitor derived inhibitors of factor

1993-07-01

1998-05-05

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530350, A61K 3857, C07K 1481

Patent

active

057474494

ABSTRACT:
A compound derived from BPTI which inhibits Factor Xa with an inhibition constant less than 50 nM.

REFERENCES:
patent: 4595674 (1986-06-01), Tschesche et al.
patent: 5032573 (1991-07-01), Auerswald et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5106833 (1992-04-01), Broze, Jr. et al.
patent: 5118668 (1992-06-01), Auerswald et al.
patent: 5239058 (1993-08-01), Vlasuk et al.
patent: 5373090 (1994-12-01), Norris et al.
patent: 5618915 (1997-04-01), Bjorn et al.
Cwirla et al., "Peptides on phage: A vast library of peptides for identifying ligants", 87 Proc. Natl. Acad. Sci. USA 6378-6382, 1990.
Hoad and Gczy, J. Immun. Methods, 136:269-278 (1991).
Roberts et al., Proc. Natl. Acad. Sci. USA, 89:2429 (1992).
Goldenberg and Creighton, J. Mol. Biol., 179:527 (1984).
Stanssens et al., Nucleic Acids Research 17:4441-4454 (1989).
Creighton et al., "Biosynthesis Processing and Evolution of Bovine Pancreatic Typsin Inhibitor", Cold Spring Harbor, Symp. Quint. Biol., 52:511-519 (1987).
Stockmans et al., "Continuous Quantitative Monitoring of Mural . . . Thrombus . . . ,", Thromb. Haemo., 65(4):425-431 (Apr. 1991).
Schulz et al, Principles of Protein Structure, pp. 14-16 (1979).
Ascenzi et al., "Binding of BPTI (Kunitz Inhibitor) to . . . Factor Xa", Biol. Chem. Hoppe-Seyler, 371:389-393 (May 1990).
Kido et al., "Kunitz-type Protease Inhibitor Found in Rat Mast Cells", J. Biol. Chem., 263:18104-18109 (Dec. 1988).
Cwirla et al., Peptides on Phage . . . , Proc. Natl. Acad. Sci., 87:6378-6382 (Aug. 1990).
Vedvick et al., J. Indus. Microbiol., 7:197-202 (1991).
Creighton et al., "Functional Evolutionary Divergence of Proteolytic Enzymes and Their Inhibitors", TIBS, 14:319-325 and 389-393 (Aug. 1989).
Fritz et al., Arzneim.-Forsch/Drug Res., 33:479-494 (1983).
Bode et al. Eur. J. Biochem., 144:185-190 (1984).
Schechter et al., Biochem. Biophys. Res. Commun., 27:157 (1967).
McCafferty et al., Nature, 348:552-554 (1990).
Kunkel, Proc. Natl. Acad. Sci. USA, 82:488-492 (1985).
Sambrook et al. in Molecular Cloning--A Laboratory Manual, Cold Spring Harbor Laboratory Press, 1989, p. 4.29.
Sanger et al., Proc. Natl. Acad. Sci. USA, 74:5463-5467 (1977).
Mackie et al., "Normal Hemostasis and its Regulation", Blood Reviews, 3:237-250 (1989).
Laskowski et al., Ann. Rev. Biochem., 49:593-626 (1980).
Remington's Pharmaceutical Sciences, Mack Publishing Co. (Ed., A.R. Gennaro 1985).
Marks et al., J. Biol. Chem., 261:7115-7118 (1986).
Goldenberg et al., Biochemistry, 27:2481-2489 (1988).
Vieira et al., Methods in Enzymology, 153:3-11 (1987).
Weislander, Anal. Biochem., 98:305-309 (1979).
Wu et al., Oligonucleotide Synthesis--A Practical Approach (Ed. Gait, M.J.), IRL Press, Oxford and Washington, D.C., pp. 135-151 (1984).
Zell et al., The EMBO Journal, 6:1809-1815 (1987).
Harlow et al., "Antibodies: A Laboratory Manual" (Cold Spring Harbor Laboratory 1988).
Furie et al., Cell, 53:505-518 (1988).
Boneu et al., Thrombosis and Haemostasis, 65:28-32 (1991).
Pelzer et al., Thrombosis and Haemostasis, 65:153-159 (1991).
ECAT Assay Procedures, A manual of Laboratory Techniques (Ed. Jespersen et al.), Kluwer Academic Publishers, Dorecht, The Netherlands (1992).

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