Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene deriv

Details Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene deriv Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene deriv

1998-02-25

2000-07-11

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5462797, 5462817, 5462847, 5462681, C07D40100

Patent

active

060875054

ABSTRACT:
Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist and/or retinoid inverse-agonist-like biological activity.

REFERENCES:
patent: 4326055 (1982-04-01), Loeliger
patent: 4391731 (1983-07-01), Boller et al.
patent: 4485252 (1984-11-01), Fuchs et al.
patent: 4539154 (1985-09-01), Krebs
patent: 4723028 (1988-02-01), Shudo
patent: 4826984 (1989-05-01), Berlin et al.
patent: 4833240 (1989-05-01), Maignana et al.
patent: 4923884 (1990-05-01), Chandraratna
patent: 4927947 (1990-05-01), Chandraratna
patent: 5013744 (1991-05-01), Chandraratna
patent: 5015658 (1991-05-01), Chandraratna
patent: 5023341 (1991-06-01), Chandraratna
patent: 5037825 (1991-08-01), Klaus et al.
patent: 5045551 (1991-09-01), Chandraratna
patent: 5053523 (1991-10-01), Chandraratna
patent: 5068252 (1991-11-01), Chandraratna
patent: 5089509 (1992-02-01), Chandraratna
patent: 5130335 (1992-07-01), Chandraratna
patent: 5134159 (1992-07-01), Chandraratna
patent: 5162546 (1992-11-01), Chandraratna
patent: 5175185 (1992-12-01), Chandraratna
patent: 5183827 (1993-02-01), Chandraratna
patent: 5202471 (1993-04-01), Chandraratna
patent: 5231113 (1993-07-01), Chandraratna
patent: 5234926 (1993-08-01), Chandraratna
patent: 5248777 (1993-09-01), Chandraratna
patent: 5264456 (1993-11-01), Chandraratna
patent: 5264578 (1993-11-01), Chandraratna
patent: 5272156 (1993-12-01), Chandraratna
patent: 5278318 (1994-01-01), Chandraratna
patent: 5324744 (1994-06-01), Chandraratna
patent: 5324840 (1994-06-01), Chandraratna
patent: 5326898 (1994-07-01), Chandraratna
patent: 5344959 (1994-09-01), Chandraratna
patent: 5346895 (1994-09-01), Chandraratna
patent: 5346915 (1994-09-01), Chandraratna
patent: 5348972 (1994-09-01), Chandraratna
patent: 5348975 (1994-09-01), Chandraratna
patent: 5349105 (1994-09-01), Chandraratna
patent: 5354752 (1994-10-01), Chandraratna
patent: 5354776 (1994-10-01), Chandratatna
patent: 5380877 (1995-01-01), Chandraratna
patent: 5391753 (1995-02-01), Chandraratna
patent: 5399561 (1995-03-01), Chandraratna
patent: 5399586 (1995-03-01), Davies et al.
patent: 5407937 (1995-04-01), Chandraratna
patent: 5414007 (1995-05-01), Chandraratna
patent: 5420145 (1995-05-01), Shudo
patent: 5426118 (1995-06-01), Chandraratna
patent: 5434173 (1995-07-01), Chandraratna
patent: 5451605 (1995-09-01), Chandraratna et al.
patent: 5455265 (1995-10-01), Chandraratna
patent: 5466861 (1995-11-01), Dawson et al.
patent: 5468879 (1995-11-01), Chandraratna
patent: 5470999 (1995-11-01), Chandraratna
patent: 5475022 (1995-12-01), Chandraratna
patent: 5475113 (1995-12-01), Chandraratna
patent: 5489584 (1996-02-01), Vuligonda et al.
patent: 5498755 (1996-03-01), Chandraratna et al.
patent: 5498795 (1996-03-01), Song et al.
patent: 5514825 (1996-05-01), Vuligonda et al.
patent: 5516904 (1996-05-01), Chandraratna
patent: 5523457 (1996-06-01), Starrett, Jr. et al.
patent: 5534516 (1996-07-01), Chandraratna
patent: 5534641 (1996-07-01), Song et al.
patent: 5543534 (1996-08-01), Vuligonda et al.
patent: 5556996 (1996-09-01), Beard et al.
patent: 5559248 (1996-09-01), Starrett, Jr. et al.
patent: 5563292 (1996-10-01), Sheh et al.
patent: 5591858 (1997-01-01), Vuligonda et al.
patent: 5599819 (1997-02-01), Chandraratna
patent: 5599967 (1997-02-01), Vuligonda et al.
patent: 5602130 (1997-02-01), Chandraratna
patent: 5602135 (1997-02-01), Chandraratna
patent: 5605915 (1997-02-01), Vuligond et al.
patent: 5616597 (1997-04-01), Chandraratna
patent: 5616712 (1997-04-01), Teng et al.
patent: 5618836 (1997-04-01), Chandraratna et al.
patent: 5618839 (1997-04-01), Starrett, Jr. et al.
patent: 5618931 (1997-04-01), Beard et al.
patent: 5618943 (1997-04-01), Vuligonda et al.
patent: 5619936 (1997-04-01), Chandraratna et al.
patent: 5648503 (1997-07-01), Vuligonda et al.
patent: 5648514 (1997-07-01), Johnson et al.
patent: 5654469 (1997-08-01), Vuligonda et al.
patent: 5663347 (1997-09-01), Chandraratna
patent: 5663357 (1997-09-01), Teng et al.
patent: 5663367 (1997-09-01), Vuligonda et al.
patent: 5672710 (1997-09-01), Beard et al.
patent: 5675024 (1997-10-01), Teng et al.
patent: 5675033 (1997-10-01), Vuligonda et al.
patent: 5677320 (1997-10-01), Chandraratna
patent: 5677323 (1997-10-01), Chandraratna
patent: 5677451 (1997-10-01), Chandraratna
patent: 5688957 (1997-11-01), Teng et al.
patent: 5696162 (1997-12-01), Chandraratna
patent: 5698700 (1997-12-01), Song et al.
patent: 5717094 (1998-02-01), Chandraratna
patent: 5723620 (1998-03-01), Vuligonda et al.
patent: 5723666 (1998-03-01), Vuligonda et al.
patent: 5728846 (1998-03-01), Vuligonda et al.
patent: 5739338 (1998-04-01), Beard et al.
patent: 5741896 (1998-04-01), Vuligonda et al.
patent: 5747542 (1998-05-01), Vuligonda et al.
patent: 5750693 (1998-05-01), Chandraratna
patent: 5760276 (1998-06-01), Beard et al.
Wierzbicki et al. (CA 88: 190510, abstract of Eur. J. Med. Chem.-Chim. THer. (1977), 12(6), 557-63), 1977.
A General Synthesis of Terminal and Internal Arylalkynes by the Palladium-Catalyzed Reaction of Alkynylzinc Reagents with Aryl Halides by Anthony O. King and Ei-ichi, J. Org. Chem., (1978) 43/2: p. 358.
Conversion of Methyl Ketones into Terminal Acetylenes and (E)-Tri-substituted Olefins of Terpenoid Origin by Ei-ichi, et al., J. Org. Chem., (1980) 45/12: p. 2526.
Sporn et al. in J. Amer. Acad. Derm . . , (1986) 15:756-764.
Liu, S. S. et al. "Systemic Pharmacokinetics of Acetylenic Retinoids in Rats", Drug Metabolism and Disposition, (1990) 18/6: 1071-1077.
Chemical Abstracts, vol. 122, No. 13, Mar. 27, 1995 abstract No. 151372m, (S. Kaku et al.).
Chemical Abstracts, vol. 117, No. 13, Sep. 28, 1992 abstract No. 124091j, (S. Sun et al.).
European Journal of Biochemistry, vol. 212, No. 1, 1993, Berlin, pp. 13-26, XP000618300 (S. Keidel et al.).
Journal of Medicinal Chemistray, vol. 39, No. 16, Aug. 2, 1996, pp. 3035-3038, Min Teng et al.
Journal of Medicinal Chemistry, vol. 37, No. 10, May 13, 1994, pp. 1508-1517, Laurence Eyrolles.
Biochemical and Biophysical Research Communications, vol. 155 No. 1, 1988, pp. 503-508.
Chemical Abstracts. vol. 121, No. 9, 1994.
Database WPi Section CH, Week 9416, Derwent Publications Ltd. London, GB; Class B05, AN 94-128759 and JP 6078266A, see English language abstract in Derwent.
Journal of Medicinal Chemistry, vol. 38, No. 16, Aug. 4, 1995, pp. 3163-3173.
Weiner, et al., "A phase I trial of topically applied trans-retinoic acid in cervical dysplasia-clinical efficacy", Investigational New Drugs, 4:241-244, 1996.
Jones, et al., "A dose-response study of 13-cis-retinoic acid in acne vulgaris", British Jornal of Dermatology, (1983) 108, 333-343.
Fekrat, et al., "The effect of Oral 13-cis-retinoic Acid on Retinal Redetachment after Surgical Repair in Eyes with Proliferative Vitreoretinopathy", Ophthalmology, vol. 102, No. 3 (Mar. 1995), pp. 412-418.
Nagpal, et al., "Separation of Transactivation and AP1 Antagonism Functions of Retinoic Acid Receptor .alpha.*", The Journal of Biological Chemistry, 270/2(1995): 923-927.
Allegretto, et al., "Transactivation Properties of Retinoic Acid and Retinoid X Receptors in Mammalian Cells and Yeast", The Journal of Biological Chemistry, vol 268, No. 35 (Dec. 15, 1993), pp. 26625-26633.
Gruapner, et al., "6'-Substituted Naphthalene-2-Carboxylic Acid Analogs, A New Class of Retinoic Acid Receptor Subtype-Specific Ligands," Biochemical and Biophysical Research Communications, vol. 179, No. 3 (Sep. 30, 1991), pp. 1554-1561.
Moore, et al., "Retinoic Acid and Interferon in Human Cancer: Mechanistic and Clinical Studies," Seminars in Hematology, 31/4, Suppl 5 (Oct. 1994), pp. 31-37.
"A Convenient Synthesis of Ethynylarenes and Diethynylarenes" by S. Takahashi et al. Synthesis (1980) p. 627-630.
Shudo et al. in Chem. Phar. Bull., (1985) 33:404-407.
Kagechika et al. in J. Med. Chem., (1988) 31:2182-2192.
Chemistry and Biology of Synthetic Retinoids by Marcia I. Dawson and William H. Okamura, published by CRC Press Inc., 1990, p. 334-335, 354.
Synthesis of 2,2'-Diacyl-1,1'-Biaryls. Regiocontrolled Protection of . . . by Mervic, et al., J. Org. Chem., (1980

Affiliated with

Also associated with

Rating

Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene deriv does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene deriv, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzo[1,2-G]-chrom-3-ene, and benzo[1,2-G]-thiochrom-3-ene deriv will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-543539