Porphyrin compounds as telomerase inhibitors

Details Porphyrin compounds as telomerase inhibitors Porphyrin compounds as telomerase inhibitors

1998-02-04

2000-07-11

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

536 266, 435 6, 534 11, 534 15, 514183, 514184, C07D48722

Patent

active

060874937

ABSTRACT:
The present invention has identified compounds with extended aromatic chromophores that bind the G-quadruplex formed by the folding of single-stranded human telomeric DNA. These compounds have been shown to be effective telomerase inhibitors and are contemplated to be useful in developing cancer treatments. A model of cationic porphyrin interaction with quadruplex DNA by intercalation has been established and in combination with structure activity relations has provided novel porphyrin compounds that exhibit discrimination between binding duplex and quadruplex DNA and show improved activity against telomerase.

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