Localized use of nitric oxide-adducts to prevent internal tissue

Details Localized use of nitric oxide-adducts to prevent internal tissue Localized use of nitric oxide-adducts to prevent internal tissue

1995-06-02

2000-07-11

O'Sullivan, Peter

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

514 2, A61K 31195

Patent

active

060874791

ABSTRACT:
A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a surface of the medical device; can be directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.

REFERENCES:
patent: 5071649 (1991-12-01), Hunter et al.
patent: 5525357 (1996-06-01), Keefer et al.
Stamler et al. "S-Nitrosylation of Protoins, etc" Proc. Natl. Acad. Sci. USA. 1992 89(1) 444-8.

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