Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1996-03-01
2000-07-11
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514815, A61K 31195
Patent
active
060873981
ABSTRACT:
The present invention provides a method of treating sickle cell anemia comprising the step of administering to an individual in need of said treatment a therapeutically acceptable dose of reducing agent. In yet another embodiment of the present invention, there is provided a method of pharmacologically correcting a post-translational modification of the .beta.-actin protein in sickled erythrocytes, comprising the step of contacting said sickled erythrocytes with a pharmacologically effective dose of a reducing agent. In still yet another embodiment of the present invention, there is provided a method of identifying a drug for use in treating sickle cell anemia. Any drug which hastens the HDSS Core Skeleton dissociation rate is tested by the in vitro ternary complex dissociation assay to test whether its effect is on HDSS beta-actin. Furthermore, drugs can be tested by the oxygenation-deoxygenation cycling assay for its ability to block ISC formation in vitro. Finally, drugs can be tested for ability to cause the conversion of preformed ISCs back to the biconcave shape.
REFERENCES:
patent: 3847545 (1974-11-01), Shanbrom et al.
Rice-Evans, Catherine and Vidyavathi Udupi. Thiol Compounds As Protective Agents In Erythrocytes Under Oxidative Stress. Free Rad. Comms., vol. 16, No. 5, pp. 315-323, UK: Harwood Academic Publishers GmbH, 1992.
Adler Benjamin Aaron
South Alabama Medical Science Foundation
Weddington Kevin E.
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