Process for preparing [1S-[1.alpha.,2.alpha.(Z),3.alpha.,4.alpha

Details Process for preparing [1S-[1.alpha.,2.alpha.(Z),3.alpha.,4.alpha Process for preparing [1S-[1.alpha.,2.alpha.(Z),3.alpha.,4.alpha

1990-09-26

1992-01-14

Kilby Scalzo, Catherine S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30700

Patent

active

050812661

ABSTRACT:
A new process for preparing [1S-[1.alpha.,2.alpha.(Z),-3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-amin o]acetyl]amino]methyl]-7-oxabicyclo [2.2.1]-hept-2-yl]-5-heptenoic acid. New intermediates are also described. [1S-(1.alpha.,2.alpha.(9Z),3.alpha.,4.alpha.]]-7-[3-[[[[(1-oxoheptyl)-amin o]acetyl]amino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid is useful in the treatment of thrombotic disease.

REFERENCES:
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patent: 4687865 (1987-08-01), Thottathil
D. Mitsunobu, "The Use of Diethyl Azodicarboxylate and Triphenyl-phosphine", Synthesis, 1981 pp. 1-28.
A. Meyers et al., "Highly Stereoselective Route", J. Org. Chem. 1981, 46, pp. 3119-3123.
Bender, "General Acid-Base Catalysis", J. Am. Chem. Soc. 1957, 79, pp. 1258-1259.
Mitsunobu et al., Journal of the American Chemical Society, vol. 94, No. 2 (1972) pp. 679-680.
G. Verlay; Houben-Weyl: "Methoden der Organischen Chemie", vol. XI/1, 1957, pp. 94-96.

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