Regiospecific carbonylation process for making acyl compounds fr

Details Regiospecific carbonylation process for making acyl compounds fr Regiospecific carbonylation process for making acyl compounds fr

1989-08-15

1992-01-14

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 88, 546168, 546257, 544224, 544406, C07D21346, C07D21322, C07D23706, C07D24110

Patent

active

050812505

ABSTRACT:
A regiospecific, catalyzed process for preparing acyl derivatives of aromatic nitrogen-containing heterocyclic compounds in which the keto group is selectively added ortho to the nitrogen atom on the aromatic ring. In the presence of a ruthenium carbonyl compound, carbon monoxide and an olefin, the aromatic heterocyclic compound which has an unsubstituted carbon atom ortho to at least one of the heterocyclic atoms adds the acyl group essentially completely in ortho position.

REFERENCES:
patent: 3840547 (1974-10-01), Mendelson
patent: 3979400 (1976-09-01), Rieger et al.
Cram et al., Organic Chemistry, Second Edition, pp. 57-58, McGraw-Hill Publishers (1964).

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