Preparation of arylamines

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546144, 560 48, 564374, 564376, 564391, 564395, 564405, 564407, C07C20910

Patent

active

055764606

ABSTRACT:
A method of preparing an arylamine compound includes reacting a metal amide comprising a metal selected from the group consisting of tin, boron, zinc, magnesium, indium and silicon, with an aromatic compound comprising an activated substituent in the presence of a transition metal catalyst to form an arylamine. The method is useful in preparing mixtures of arylamines for use in screening for pharmaceutical and biological activity and in preparing poly(anilines).

REFERENCES:
patent: 5233090 (1993-08-01), Shimada et al.
patent: 5319009 (1994-06-01), Sasaki et al.
patent: 5382692 (1995-01-01), Shimada et al.
patent: 5403950 (1995-04-01), Shimada et al.
"Amido-derivatives of Metals and Metalloids. Part IX. Reactions of Tin(IV) and Titanium (IV) Amides with Compounds having Carbonyl and Sulphinyl Multiple Bonds" Chandra et al. J. Chem. Soc. (C) 1969, 2565-8 (1969).
"Mechanism and Models for Copper Mediated Nucleophilic Aromatic Substitution. 2. A Single Catalytic Species from Three Different Oxidation States of Copper in an Ullmann Synthesis of Triarylamines" Paine, A. J. J. Chem Soc. 109, 1496-1502 (1987).
"Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Aza Dienes. Studies on the Total Synthesis of Lavendamycin: Investigative Studies on the Preparation of the CDE .beta.-Carboline Ring System and AB Quinoline-5, 8-quinone Ring System" Boger et al. J. Org. Chem. 50, 5782-5789 (1985).
"Catalytic and Stoichiometric Metal-Mediated C-N Bond-Forming Processes" Hartwig et al. Paper #235 at the 207th Meeting of the American Chemical Society, Mar. 13-17, 1994, San Diego, California (Abstract only).
"Palladium-Catalyzed Formation of Carbon-Nitrogen Bonds. Reaction Intermediates and Catalyst Improvements in the Hetero Cross-Coupling of Aryl Halides and Tin Amides" Paul et al. J. Am. Chem. Soc. 116, 5969-5970 (1994).
"Aromatic Substitution by the S.sub.RN 1 Mechanism" Bunnett, J. F. Accounts of Chemical Research 11, 413-420 (1978).
"Studies on nucleophilic substitution reactions with cyclopentadienyliron complexes of some chloroarenes and nitroarenes and syntheses and substituted arenes by demetallation of the substitution products" Abd-El-Aziz et al. Journal of Organometallic Chemistry 348, 95-107 (1988).
"Amino-derivatives of Metals and Metalloids. Part I. Preparation of Aminostannanes, Stannylamines, and Stannazanes" Jones, K. and Lappert, M. F. Journal of the Chemical Society 1965 1944-1951 (1965).
"Palladium-Catalyzed Aromatic Amination of Aryl Bromides with N,N-Di-Ethylamino-Tributyltin" Kosugi et al. Chemistry Letters 1983 927-928 (1983).
"Organic Tin-Nitrogen Compounds" Jones, K. and Lappert, M. F. Organometallic Chemistry Review 1, 67-92 (1966).
"Nucleophilic Aromatic Substitution Reactions of 1--Methoxy--2--(diphenylphosphinyl)naphthalene with C--, N--, and O--Nucleophiles: Facile Synthesis of Diphenyl(1-substituted-2--naphythyl)phosphines" Hattori et al. Synthesis 1994 199-202 (Feb. 1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Preparation of arylamines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of arylamines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of arylamines will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-542172

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.