Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-05
1996-11-19
Springer, David B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D20726
Patent
active
055764479
ABSTRACT:
The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.
The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
REFERENCES:
patent: 4302472 (1981-11-01), Cozzi et al.
patent: 5239113 (1993-08-01), Bovy et al.
patent: 5344957 (1994-09-01), Bovy et al.
Freidinger et al.. "Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides" J. Org. Chem.: 47, 104-109 (1982).
Kottirsch et al. "Fibrinogen Receptor Antagonists Containing a Gamma-Lactam Gly-Asp Isostere" Bioorganic & Medicinal Chemistry Letters, vol. 3, No. 8, pp. 1675-1680 (1993).
Abood Norman A.
Flynn Daniel L.
Laneman Scott A.
Nosal Roger
Schretzman Lori A.
G. D. Searle & Co.
Kovacevic Cynthia S.
Springer David B.
Williams Roger A.
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