Dihydropyridinecarboxylic acid anhydrides

Details Dihydropyridinecarboxylic acid anhydrides Dihydropyridinecarboxylic acid anhydrides

1994-10-28

1996-11-19

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21379, C07D21380, A61K 3144

Patent

active

055764398

ABSTRACT:
The invention relates to the compounds of formula I ##STR1## wherein R is lower alkyl or hydrogen; R.sub.1 is hydrogen, lower alkyl or aryl-lower alkyl; R.sub.2 is hydrogen, nitro, cyano trifluoromethyl, halo, lower alkoxy, lower alkyl, lower alkoxycarbonyl, aminocarbonyl or mono- or di-lower alkylaminocarbonyl, amino or mono- or di-lower alkylamino; and pharmaceutically acceptable salts thereof when R.sub.1 is hydrogen; which are useful as endothelin antagonists.

REFERENCES:
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patent: 4672068 (1987-06-01), Kutsuma et al.
patent: 4672071 (1987-06-01), Clark et al.
patent: 4999362 (1991-03-01), Gandolfi et al.
Chem. Pharm. Bull., vol. 9, No. 1, 1991, pp. 108-111.
Bisorganic & Medicinal Chemistry Letters, vol. 3, No. 10, pp. 2099-2104, 1993.
J. Clin. Invest., vol. 93, May 1994, pp. 2141-2148.
Experimental Biol. '94, Apr. 24-28, 1994 Anaheim, CA, Poster Presentation.
Chem. Pharm. Bull., vol. 39, No. 1, pp. 108-111 1991.

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