Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-05-19
1996-11-19
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
5303877, 5303879, C07K 1482, C07K 1632
Patent
active
055764223
ABSTRACT:
A new human gene termed MCC is disclosed. Methods and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results suggest that MCC is a tumor suppressor. A MCC protein and antibody are disclosed.
REFERENCES:
Ashton-Rickardt, et al., "High Frequency of APC Loss in Sporadic Colorectal Carcinoma Due to Breaks Clustered in 5q21-22",Oncogene , 4:1169-1174, (1989).
Bodmer, et al., "Localization of the Gene for Familial Adenomatous Polyposis on Chromosome 5", Nature, 328:614-619, (1987).
Delattre, et al., "Multiple Genetic Alterations in Distal and Proximal Colorectal Cancer", The Lancet, vol. II, No. 8659, pp. 353-356 (Aug. 12, 1989).
Fearon, et al., "Identification of a Chromosome 18q Gene That Is Altered in Colorectal Cancers", Science, 247:49-56 (1990).
Fearon, et al., "A Genetic Model for Colorectal Tumorigenesis", Cell, 61:759-767 (1990).
Herrera, et al., "Brief Clinical Report: Gardner Syndrome in a Man With an Interstitial Deletion of 5q", Am. J. of Med. Genet., 25:473-476 (1986).
Monaco, et al., "Isolation of Candidate cDNAs for Portions of the Duchenne Muscular Dystrophy Gene", Nature, 323:646-650 (1986).
Nakamura, et al., "Localization of the Genetic Defect in Familial Adenomatous Polyposis Within a Small Region of Chromosome 5", Am. J. Hum. Genet., 43:638-644 (1988).
Okayama, et al., "Rapid, Nonradioactive Detection of Mutations in the Human Genome by Allele-Specific Amplification", J. Lab Clin. Med., 114:105-113 (1989).
Rommens, et al., "Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping", Science, 245:1059-1065 (1989).
Ruano, et al., "Direct Haplotyping of Chromosomal Segments from Multiple Heterozygotes Via Allele-Specific PCR Amplification", Nucleic Acids Res., 17:8392 (1989).
Sasaki, et al., "Loss of Constitutional Heterozygosity in Colorectal Tumors from Patients with Familial Polyposis Coli and Those with Nonpolyposis Colorectal Carcinoma,"Cancer Research, 49:4402-4406, 1989.
Viskochil, et al., "Deletions and a Translocation Interrupt a Cloned Gene at the Neurofibromatosis Type 1 Locus", Cell, 62:187-192 (1990).
Vogelstein, et al., "Genetic Alterations During Colorectal-Tumor Development", New Eng. J. Med., 319:525-532 (1988).
Wallace, et al., "Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients", Science, 249:181-186 (1990).
Wu, et al., "The Ligation Amplification Reaction (LAR)--Amplification of Specific DNA Sequences Using Sequential Rounds of Template-Dependent Ligation", Genomics, 4:560-569, 1989.
International Search Report of Co-pending PCT Application PCT/US92/00377.
Tanaka, et al., "Suppression of Tumorigenicity in Human Colon Carcinoma Cells by Introduction of Normal Chromosome 5 or 18", Nature, 349:340-342 (1991).
Kinzler, et al., "Identification of a Gene Located at Chromosome 5q21 that is Mutated in Colorectal Cancers", Science, 251:1366-1370 (1991).
Marx, "Gene Identified for Inherited Cancer Susceptibility", Science, 253:616 (1991).
Baker et al., "Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas", Science, 244:217-221 (1989).
Levy et al., PNAS 76:6552-6556, Dec. 1, 79.
Perlman et al., Cancer Genet Cytogenet 82:30-34 (1995).
Kinzler Kenneth W.
Nakamura Yusuke
Vogelstein Bert
White Raymond
Hutzell Paula K.
Johnson Nancy A.
The Cancer Institute
The Johns Hopkins University
University of Utah
LandOfFree
MCC protein and antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with MCC protein and antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MCC protein and antibody will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-541913