Method of producing antitumor effect using quinazolin-4-one deri

Details Method of producing antitumor effect using quinazolin-4-one deri Method of producing antitumor effect using quinazolin-4-one deri

1990-09-05

1992-01-14

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544283, 544284, 544285, 544286, 544287, 544289, A61K 31505, C07D23990

Patent

active

050811240

ABSTRACT:
A quinazoline of the formula: ##STR1## wherein R.sup.1 is alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, aryl, aryloxy, arylalkyl, halogeno, hydroxy, mercapto, pyridylthio, pyrimidinylthio, or substituted alkyl or alkoxy;

REFERENCES:
patent: 3472851 (1969-10-01), Davoll
patent: 4447608 (1984-05-01), Jones et al.
"Eur. J. Cancer Oncol.", vol. 24, No. 4, 1988, pp. 733-736.
"Eur. J. Cancer Oncol.", vol. 24, No. 4, 1988, pp. 769-775.
"Journal of Hepatology", 1987, 4:349-356; Basserdine, et al.
"Journal of Clinical Oncology", vol. 4, No. 8, 1986, pp. 1245-1252.

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