Use of 5-alkylpyridazine derivatives as drugs active on the chol

Details Use of 5-alkylpyridazine derivatives as drugs active on the chol Use of 5-alkylpyridazine derivatives as drugs active on the chol

1990-02-07

1992-01-14

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514247, A61K 3150, A61K 31535

Patent

active

050811193

ABSTRACT:
The invention relates to the use of 5-alkylpyridazine derivatives of the formula ##STR1## in which R.sub.1 is a C.sub.1 -C.sub.4 alkyl group or a phenyl group and R.sub.2 and R.sub.3 independently are a C.sub.1 -C.sub.4 alkyl group, or R.sub.2 and R.sub.3, taken with the nitrogen atom to which they are bonded, form a morpholino group, or one of their pharmaceutically acceptable salts, for the preparation of pharmaceutical compositions for combating pathological conditions associated with a cortical cholinergic deficiency, especially for the treatment of degenerative syndromes associated with senescence.

REFERENCES:
patent: 4508720 (1985-04-01), Jean-Paul Kan et al.
Van der Brempt, et al., "Structure Analysis of Minaprine Analogs: 3-Morpholinium Ethylamin-5-Methyl-6-Phenylpyridazinium Oxalate, Oxalic Acid" Chemical Abstracts 103:552, No. 204113u (1985).
Hammer et al., "Pirenzepine Distinguishes Between Different Subclasses of Muscarinic Receptors," Nature 283:90-92 (1980).
Hulme et al., "The Binding of Antagonists to Brain Muscarinic Receptors," Molecular Pharmacology 14:737-750 (1978).
Watson et al., "[.sup.3 H]Pirenzepine Selectively Identifies a High Affinity Population of Muscarinic Cholinergic Receptors in the Rate Cerebral Cortex.sup.1," Life Science 31:2019-2023 (1982).
Worms et al., "Antagonism by Cholinomimetic Drugs of the Turning Induced by Intrastriatal Pirenzepine in Mice," Psychopharmacology 93:489-493 (1987).

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