Process for preparing polycyclic heterocycles having a pyran rin

Details Process for preparing polycyclic heterocycles having a pyran rin Process for preparing polycyclic heterocycles having a pyran rin

1977-02-03

1980-09-16

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424263, C07D40500, A01N 900

Patent

active

042231515

ABSTRACT:
A process applicable to the preparation of a wide variety of novel polycyclic heterocycles having a newly-formed pyran ring is disclosed. According to the process an aromatic nucleus bearing an ethanol group, for example, 3,4-dimethoxyphenethyl alcohol, is condensed with an aldehyde or ketone or a protected aldehyde or ketone, for example, aminoactaldehyde diethyl acetal, in the presence of an acid catalyst to afford the polycyclic heterocycle, for example, 6,7-dimethoxy-1-isochromanmethylamine. The new heterocycles so formed are useful for preparing derivatives having antiinflammatory, antibacterial or antifungal activities.

REFERENCES:
Ziegler et al., "Chem. Abst.", vol. 75 (1971) p. 129587z.

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