Methods and apparatus for synthesizing labeled combinatorial che

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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436524, 436525, 436526, 436527, 436528, 530334, 435 4, G01N 33543, G01N 33544

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active

060871865

ABSTRACT:
The present invention provides labeled synthetic libraries of random oligomers and methods and apparatus for generating labeled synthetic oligomer libraries. Each member of such a library is labeled with a unique identifier tag that specifies the structure or sequence of the oligomer. In a preferred embodiment of the present invention the identifier tag is a microchip that is pre-encoded or encodable with information that is related back to a detector when the identifier tag is pulsed with electromagnetic radiation.

REFERENCES:
patent: 5351052 (1994-09-01), D'Hont et al.
patent: 5525962 (1996-06-01), Urbas et al.
Brenner et al., "Encoded Combinatorial Chemistry", Proc. Natl. Acad. Sci. USA, 89:5381-5383 (1992).
Fodor et al., "Light-Directed, Spatially Addressable Parallel Chemical Synthesis", Science, 251:767-773 (1991).
Furka et al., "General Method for Rapid Sythesis of Multicomponent Peptide Mixtures", Int. J. Peptide Protein Res., 37:487-493 (1991).
Gallop et al., "Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries", Journal of Medicinal Chemistry, 37:1233-1251 (1994).
Geysen et al., "Strategies for Epitome Analysis Using Peptide Synthesis", Journal of Immunological Methods, 102:259-274 (1987).
Gordon et al., "Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions", Journal of Medicinal Chemistry, 37:1385-1401 (1994).
Houghten, "General Method for the Rapid Solid-Phase Synthesis of Large Numbers of Peptides: Specificity of Antigen-Antibody Interaction at the Level of Individual Amino Acids", Proc. Natl. Acad. Sci. USA, 82:5131-5135 (1985).
Jung et al., "Multiple Peptide Synthesis Methods and Their Applications", Angew. Chem. Int. Ed. Engl., 31:367-383 (1992).
Kerr et al., "Encoded Combinatorial Peptide Libraries Containing Non-Natural Amino-Acids", J. Am. Chem. Soc., 115:2529-2531 (1993).
Needels et al., "Generation and Screening of an Oligonucleotide-Encoded Sythetic Peptide Library", Proc. Natl. Acad. Sci. USA, 90:10700-10704 (1993).
Nielsen et al., "Synthetic Methods for the Implementation of Encoded Combinatorial Chemistry", J. Am. Chem. Soc., 115:9812-9813 (1993).
Ohlmeyer et al., Complex Synthetic Chemical Libraries Indexed with Molecular Tags, Proc. Natl. Acad. Sci. USA, 90:10922-10926 (1993).
E.J. Moran et al. J. Amer. Chem. Soc., 1995, vol. 117, pp. 10787-10788.

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