Hexahydrobenzo(A)phenanthridine compounds

Details Hexahydrobenzo(A)phenanthridine compounds Hexahydrobenzo(A)phenanthridine compounds

1989-03-17

1991-09-10

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 48, C07D21558

Patent

active

050475363

ABSTRACT:
Trans-hexahydrobenzophenanthridines of the formula ##STR1## wherein R is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sub.1 is hydrogen, benzoyl or pivaloyl; and x is hydrogen, chloro, bromo, iodo or a group of the formula OR.sub.2, are novel ligands for dopamine receptors.

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Laus, G., Tourwe, D., and Van Binst, G., Benzo and Indoloquinolizidine Derivatives.sup.1 XIX, The Synthesis and Pharmacological Activity of Some Quinolizidine Derivatives, Analogues of Butaclamol, Heterocycles, vol. 22, No. 2, p. 311, 1984.
Riggs, R. M., Studies Directed Toward the Design of Specific Dopamine D-1/DA-1 Agonists and Antagonists, A Thesis Submitted to the Faculty of Purdue university-In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy, 1986.

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