Compositions that specifically bind to colorectal cancer cells a

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 253, 530350, C12Q 168

Patent

active

060871091

ABSTRACT:
Conjugated compounds that comprise an ST receptor binding moiety and an active moiety that is an antisense molecule are disclosed. Pharmaceutical compositions which comprise conjugated compounds that comprise an ST receptor binding moiety and an active moiety that is an antisense molecule are disclosed including pharmaceutical compositions that have enteric formulations. Methods of treating an individual suspected of suffering from colorectal cancer and methods of preventing colorectal cancer are disclosed.

REFERENCES:
patent: 4584268 (1986-04-01), Ceriani et al.
patent: 4601896 (1986-07-01), Nugent
patent: 4729893 (1988-03-01), Letcher et al.
patent: 4849227 (1989-07-01), Cho
patent: 5087616 (1992-02-01), Myers et al.
patent: 5160723 (1992-11-01), Welt et al.
patent: 5166320 (1992-11-01), Wu et al.
patent: 5237051 (1993-08-01), Garbers et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5330892 (1994-07-01), Vogelstein et al.
patent: 5350741 (1994-09-01), Takada
patent: 5352775 (1994-10-01), Albertsen et al.
patent: 5399347 (1995-03-01), Trentham et al.
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5518888 (1996-05-01), Waldman
patent: 5585479 (1996-12-01), Hoke et al.
patent: 5601990 (1997-02-01), Waldman
Almenoff et al., "Ligand-based Histochemical Localization and Capture of Cells Expressing Heat-Stable Enterotoxin Receptors", Molecular Microbiology, 1993, 8, 865-873 903.
Barchel et al., "Radioimaging and Radiiotherapy" New York, 1983.
Bjorn et al., "Antibody-Pseudomonas Exotoxin A Conjugates Cytotoxic to Human Breat Cancer Cells In Vitro", Cancer Res., 1986, 46, 3262-3267.
Bjorn et al., "Evaluation of Monoclonal Antibodies for the Development of Breast Cancer Immunotoxins", Cancer Res., 1985, 45, 1214-1221.
Bodansky et al., "Peptide Synthesis", John Wiley and Sons, 2d Ed., 1976.
Burgess et al., "Biological Evaluation of a Methanol-Soluble, Heat-Stable Escherichia coli Enterotoxin in Infant Mice, Pigs, Rabbits, and Calves", Infection and Immunity, 1978, 21, 526-531.
Cawley et al., "Epidermal Growth Factor-Toxin A Chain Conjugates: EGF-Ricin A is a Potent Toxin While EGF-Diphtheria Fragment A is Nontoxic", Cell, 1980, 22, 563-570.
Chan et al., "Amino Acid Sequence of Heat-stable Enterotoxin Produced by Escherichia coli Pathogenic for Man", J. Biol. Chem., 1981, 256, 7744-7746.
Chung et al., "Enzymatically Active Peptide from the Adenosine Diphosphate-Ribosylating Toxin of pseudomonas Aeruginosa" Infection and Immunity, 1977, 16, 832-841.
Cohen, M., et al., "Receptors for Escherichia coli Heat Stable Enterotoxin in Human Intestine and in a Human Intestinal Cell Line (Caco-2)", J. Cellular Physiol., 1993, 156, 138-144.
Corstens et al., "Chemotactic Peptides: New Locomotion for Imaging Infection?" J. Nucl. Med., 1991, 32(3), 491-494.
Cumber et al., "Preparation of Antibody-Toxin Conjugates", Methods in Enzymology, 1985, 112, 207-225.
Currie et al., "Guanylin: An Endogenous Activator of Intestinal Guanylate Cyclase", Proc. Natl. Acad. Sci. USA, 1992, 89, 947-951.
de Sauvage, F. et al., "Primary Structure and Functional Expression of the Human Receptor for Escherichia coli Heat-stable Enterotoxin", J. Biol. Chem., 1991, 266, 17912-17918.
Dreyfus et al, "Chemical Properties of Heat-Stable Enterotoxins Produced by Enterotoxigenic Escherichia Coli of Different Host Origins", Infection and Immunity, 1983, 42, 539-548.
Eckelman et al., "Comparison of .sup.99m Tc and .sup.111 In Labeling of Conjugated Antibodies", Nucl. Med. Biol., 1986, 13, 335-343.
Evans et al., "Differences in the Response of Rabbit Small Intestine to Heat-Labile and Heat-Stable Enterotoxins of Escherichia Coli", Infection and Immunity, 1973, 7, 873-880.
Fischman et al., "A Ticket to Ride: Peptide Radiopharmaceuticals", J. Nucl. Med., 1993, 34, 2253-2263.
Fitzgerald et al., "Adenovirus-Induced Release of Epidermal Growth Factor and Pseudomonas Toxin into the Cytosol of KB Cells during Receptor-Mediated Endocytosis", Cell, 1983, 32, 607-617.
Fitzgerald, "Construction of Immunotoxins Using Pseudomonas Exotoxin A", Methods in Enzymology, 1987, 151, 139-145.
Franz et al., "The Production of .sup.99m Tc-Labeled Conjugated Antibodies Using A Cyclam-Based Bifunctional Chelating Agent", J. Nucl. Med. Biol., 1987, 14, 569-572.
Giannella et al., "Development of a Radioimmunoassay for Escherichia coli Heat-Stable Enterotoxin: Comparison with the Suckling Mouse Bioassay", Infection and Immunity, 1981, 33, 186-192.
Gros, O., "Biochemical Aspects of Immunotoxin Preparation", J. Immunol. Meth., 1985, 81, 283-297.
Guarino, A. et al., "T.sup.84 Cell Receptor Binding and Guanyl Cyclas Activaiton by Escherichia coli Heat-Stable Toxin", Am. J. Physiol., 1987, 253 (Gastrointest. Liver Physiol. 16): G775-780.
Gyles, C.L., "Discussion: Heat-Labile and Heat-Stable Forms of the Enterotoxin from E. Coli Strains Enteropathogenic For Pigs", Ann N.Y. Acad. Sci., 1979, 16, 314-321.
Hakki et al., "Solubilization and Characterization of Functionally Coupled Escherichia Coli Heat-Stable Toxin Recpeptors and Particulate Guanylate Cyclase Associated with the Cytoskeleton Compartment of Intestinal Membranes", Int. J. Biochem, 1993, 25, 557-566.
Hugues et al., "Identification and Characterization of a New Family of High-Affinity Receptors for Escherichia Coli Heat-Stable Enterotoxin in Rat Intestinal Membranes", Biochem., 1991, 30, 10738-10745.
Humm et al., "Dosimetric Aspects of Radiolabeled Antibodies for Tumor Therapy", J. Nucl. Med., 1986, 27, 1490-1497.
Klipstein et al., "Development of a Vaccine of Cross-Linked Heat-Stable and Heat-Labile Enterotoxins that Protects Against Escherichia Coli Producing Either Enterotoxin", Infection and Immunity, 1982, 37, 550-557.
Krejcarek and Tucker, "Covalent Attachment of Chelating Groups to Macromolecules", Biochem. Biophys. Res. Commun., 1977, 77, 581-585.
Kwok, "Calculation of Radiation Doses for Nonuniformly Distributed .beta. and .gamma. Radionuclides in Soft Tissue", Med. Phys., 1985, 12, 405-412.
Leonard et al., "Kinetics of Protein Synthesis Inactivation in Human T-Lymphocytes by Selective Monoclonal Antibody-Ricin Conjugates", Cancer Res., 1985, 45, 5263-5269.
Magerstadt, M., Antibody Conjugates and Malignant DiseaseBoca Raton: CRC Press, 110-152 (1991).
Masuho et al., "Importance of the Antigen-Binding Valency and the Nature of the Cross-Linking Bond in Ricin A-Chain Conjugates with Antibody", J. Biochem., 1982, 91, 1583-1591.
Merrifield, "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Am. Chem. Society, 1963, 15, 2149-2154.
Michel and Dirkx, "Fluorescence Studies of Nucleotides Binding to Diphtheria Toxin and Its Fragment A", Biochimica et Biophysia Acta, 1974, 365, 15-27.
Moseley et al., "Isolation and Nucleotide Sequence Determination of a Gene Encoding a Heat-Stable Enterotoxin of Escherichia Coli", Infection and Immunity, 1983, 39, 1167-1174.
Okamoto et al., "Substitutions of Cysteine Residues of Escherichia Coli Heat-Stable Enterotoxin By Oligonucleotide-Directed Mutagenesis", Infection and Immunity, 1987, 55, 2121-2125.
Richardson et al., "Astatine (.sup.211 At) as a Therapeutic Radionuclide. The Plasma: Blood Cell distribution in Vitro", Nucl. Med. Biol., 1986, 13, 583-584.
Sack, "Human Diarrheal Disease Caused by Enterotoxigenic Escherichia Coli", Ann. Rev. Microbiol., 1975, 29, 333-353.
Shimonishi et al., "Mode of Disulfide Bond Formation of a Heat-Stable Enterotoxin (ST.sub.h) Produced by a Human Strain of Enterotoxigenic Escherichia Coli", FEBS Letters, 1987, 215, 165-170.
So and McCarthy, "Nucleotide Sequence of the Bacterial Transposon Tn1681 Encoding a Heat-Stable (ST) Toxin and Its Identification in Enterotoxigenic Escherichia Coli Strains", Proc. Natl. Acad. Sci. USA, 1980, 77, 4011-4015.
Spitler et al., "Therapy of Patients with Malignant Melanoma Using a Monoclonal Antimelanoma Antibody-Ricin A Chain Immunotoxin", Cancer Res., 1987, 47, 1717-1723.
Steinstra.beta.er et al., "Selection of Nuclides for Immunoscintigraphy/Immunotherapy", J. Nucl. Med., 1988, 5, 875.
Thompson, "Escherichia coli Heat-Stable Enterotoxins and their Receptors", Path

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions that specifically bind to colorectal cancer cells a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions that specifically bind to colorectal cancer cells a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions that specifically bind to colorectal cancer cells a will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-540819

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.