Process for preparing homocystein analogs useful as intermediate

Details Process for preparing homocystein analogs useful as intermediate Process for preparing homocystein analogs useful as intermediate

1996-02-05

1997-04-01

Grumbling, Matthew V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560125, C07C38100

Patent

active

056167750

ABSTRACT:
Homocysteine analogs of the formula ##STR1## wherein P.sub.1 is a nitrogen protecting group and R.sub.6 is alkyl, substituted alkyl or benzyl are prepared by esterifying N-protected L-methionine, oxidizing, treating the resulting sulfoxide with an acid anhydride, treating the resulting product with an alkali metal hydroxide followed by removal of formaldehyde and the treatment with an acid anhydride or acid halide. The L-homocysteine analogs are useful as intermediates in the preparation of compounds containing a fused bicyclic ring.

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