Method for estimating the biological potential of a selected car

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 721, 436 63, 436 64, 436813, 128749, G01N 3353, G01N 33574

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active

056164696

ABSTRACT:
A method for estimating the biologic potential of prostate carcinoma in a patient is disclosed, comprising the steps of (a) obtaining a tissue sample of prostate carcinoma from a patient, and (b) quantifying the vascularity of the tissue sample, and therefrom estimating the metastatic potential of the prostate carcinoma. Also disclosed is a method for estimating the biologic potential of a selected carcinoma in a patient, comprising the steps of (a) obtaining a biopsy specimen from a carcinoma by needle biopsy, and (b) quantifying the vascularity of the biopsy specimen, and therefrom estimating biologic potential of the selected carcinoma.

REFERENCES:
Brem et al., "Tumor Angiogenesis: A Quantitative Method for Histologic Grading," J. Natl. Cancer Inst. 48(2):347-356, 1972.
Sillman et al., "The Significance of Atypical Vessels and Neovascularization in Cervical Neoplasia," Am. J. Obstet. Gynecol. 139(2):154-159, 1981.
Zincke et al., "Relationship Between Grade and Stage of Adenocarcinoma of the Prostate and Regional Pelvic Lymph Node Metastases," J. Urology 128:498-501, 1982.
Srivastava et al., "Neovascularization in Human Cutaneous Melanoma: A Quantitative Morphological and Doppler Ultrasound Study," Eur. J. Cancer Clin. Oncol. 22(10):1205-1209, 1986.
Yamaura and Sato, "Quantitative Studies on the Developing Vascular System of Rat Hepatoma," J. Natl. Cancer Inst. 53(5):1229-1240, 1974.
Chodak et al., "Angiogenic Activity as a Marker of Neoplastic Lesions of the Human Bladder," Ann Surg. 192(6):762-771, 1980.
Jensen et aal., "Angiogenesis Induced by Normal Human Breast Tissue: A Probable Marker for Precancer," Science 218:293-295, 1982.
Liotta et al., "Quantitative Relationships of Intravascular Tumor Cells, Tumor Vessels, and Pulmonary Metastases Following Tumor Implantation," Cancer Research 34:997-1004, 1974.
Paulson et al., "Predictors of Lymphatic Spread in Prostatic Adenocarcinoma: Uro-Oncology Research Group Study," J. Urology 123:697-699, 1980.
Khominsky and Schamaev, " Uber die Vaskularisation der neuroektodermalen Geschw ulste von Verschiedenen Malignit atsgraden," Arch. Geschwulsforsch. 37(2):136-151, 1971 (describes vascularization of neuroectodermal tumors of various malignancy grades).
Trop e, "The Preoperative Diagnosis of Malignancy of Ovarian Cysts," Neoplasma 28(1):117-121, 1981.
McCullough et al., "Carcinoma of the Prostate and Lymphatic Metastases," J. Urology 111:65-71, 1974.
Maiorana and Gullino, "Acquisition of Angiogenic Capacity and Neoplastic Transformation in the Rat Mammary Gland," Cancer Research 38:4409-4414, 1978.
Folkman and Klagsbrun, "Angiogenic Factors," Science 235:442-447, 1987.
Folkman et al., "Induction of Angiogenesis During the Transition from Hyperplasia to Neoplasia," Nature 339:58-61, 1989.
Bram et al., "Angiogenesis as a Marker of Preneoplastic Lesions of the Human Breast," Cancer 41:239-244, 1978.
Brem et al., "Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia," Science 195:880-882, 1977.
Chandrasekhar et al., "Ultrasonically Guided Percutaneous Biopsy of Peripheral Pulmonary Masses," Chest 70(5):627-630, 1976.
Sawhney et al., "Tru-Cut Biopsy of Mediastinal Masses Guided by Real-Time Sonography," Clinical Radiology 44:16-19, 1991.
Tatematsu et al., "Neovascularization in Benign and Malignant Urinary Bladder Epithelial Proliferative Lesions of the Rat Observed in Situ by Scanning Electron Microscopy and Autoradiography," Cancer Research 38:1792-1800, 1978.
Ackerman, "The Blood Supply of Experimental Liver Metastases. IV. Changes in Vascularity with Increasing Tumor Growth," Surgery 75(4):589-596, 1974.
Brem, "The Role of Vascular Proliferation in the Growth of Brain Tumors," Clinical Neurosurgery, Ch. 33, pp. 440-453, 1975.
Auerbach, "Angiogenesis Induction by Tumors, Embryonic Tissues, and Lymphocytes," Cancer Research 36:3435-3440, 1976.
Kramer et al., "Comparative Morphology of Primary and Secondary Deposits of Prostatic Adenocarcinoma," Cancer 48(2):271-273, 1981.
Rastinejad et al., "Regulation of the Activity of a New Inhibitor of Angiogenesis by a Cancer Suppressor Gene," Cell 56:345-355, 1989.
Folkman and Cotran, "Relation of Vascular Proliferation to Tumor Growth," pp. 207-248.
Folkman J., "Tumor Angiogenesis: Therapeutic Implications," New Eng. J. Med. 285(21):1182-1186, 1971.
H.C. Van Der Linden et al., "Morphometry and Breast Cancer: II. Characterization of Breast Cancer Cells with High Malignant Potential in Patients with Spread to Lymph Nodes," Biological Abstracts 82(7):Abstract No. 64957, 1986.
Shingo Takano et al., "Ultrastructure of Glioma Vessel: Morphometric Study for Proliferative Potential of Endothelial Cells" Biological Abstracts 92:1991, Abstract No. 30882.
Chodak et al., "Angiogenic Activity as a Marker of Neoplastic and Preneoplastic Lesions of the Human Bladder," Biological Abstracts 71(10): Abstract No. 67868, 1981.
Weidner et al. (N. Engl. J. Med, vol. 324, No. 1, pp. 1-8, 1991).
Srivastava et al. (Am. J. Pathol., vol. 133, No. 2, pp. 419-423, 1988).
Folkman (J. Natl. Cancer Inst., vol. 82, No. 1, pp. 4-6, 1990).

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