Ribozyme-mediated inhibition of bovine leukemia virus

Details Ribozyme-mediated inhibition of bovine leukemia virus Ribozyme-mediated inhibition of bovine leukemia virus

Filed on

1995-08-28

Date issued

1997-04-01

Examiner

LeGuyader, John L.

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Measuring or testing process involving enzymes or...

SubSubClass

Involving nucleic acid

Other Related Categories

435 9131, 4351723, 4353201, 536 231, 536 232, 536 245, 514 44, C12Q 168, C12N 1585, C07H 2104, A61K 4800

Type

Patent

Status

active

Patent number

056164661

Description

ABSTRACT:
A ribozyme is provided which is capable of cleaving bovine leukemia virus (BLV) RNA both in a cell free system and intracellularly. The ribozyme of the present invention comprises the hammerhead motif flanked by antisense sequences complementary to BLV rex/tax RNA. Introduction of the ribozyme into BLV-infected cells results in inhibition of BLV protein expression, allowing for the control of BLV infection.

REFERENCES:
patent: 5190931 (1993-03-01), Inouye
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Johnston et al. Science 260:1286-1293 (1993).
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Tikhonenko et al. J. Cell. Biochem. Suppl. 15D, p. 37, abstract (1991).
"A Listing of Antisense Patents, 1971-1991," Anti. Res. Dev. 1:219-226 (1991).
Cantor, G. H. et al., "Antisense Oligonucleotide Inhibition of Bovine Leukemia Virus tax Expression in a Cell-Free System," Anti. Res. Dev. 2:147-152 (1992).
Cantor, G.H. et al., "Ribozyme Cleaves rex/tax mRNA and Inhibits Bovine Leukemia Virus Expression," PNAS (USA) 90:1-5 (1993).
Willems, L. et al., "In Vivo Infection of Sheep by Bovine Leukemia Virus Mutants," J. Virol. 67:4078-4085 (1993).

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