Process for the production of threo-4-alkoxy-5- (arylhydroxymeth

Details Process for the production of threo-4-alkoxy-5- (arylhydroxymeth Process for the production of threo-4-alkoxy-5- (arylhydroxymeth

1991-12-17

1993-04-06

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30732

Patent

active

052005313

ABSTRACT:
Threo-4-alkoxy-5-(arylhydroxymethyl)-2(5H)-furanones are obtained by condensation of 4-alkoxy-2(5H)-furanones with benzaldehydes in the presence of lithium hydroxide without contamination by the corresponding erythro stereoisomers. The condensation is preferably performed in aqueous acetonitrile and the product is precipitated from the alkaline reaction mixture by the addition of water. The products that can be produced according to the process of the invention are known pharmaceutical active ingredients with anticonvulsive or antiepileptic action.

REFERENCES:
patent: 4855320 (1989-08-01), Chatterjee et al.
Pelter et al., Tetrahedron Letters, No. 18, (1970, pp. 1627-1630).
Fieser, "Fieser and Fieser's Reagents For Organic Synthesis", vol. 8, (1980), p. 268.
Pelter et al., J. Chem. Soc. Perkin Trans. I, (1987), pp. 717 to 742.

Affiliated with

Also associated with

Rating

Process for the production of threo-4-alkoxy-5- (arylhydroxymeth does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of threo-4-alkoxy-5- (arylhydroxymeth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of threo-4-alkoxy-5- (arylhydroxymeth will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-537855