Acetic acid derivatives having pharmacological activity and comp

Details Acetic acid derivatives having pharmacological activity and comp Acetic acid derivatives having pharmacological activity and comp

1975-06-18

1977-05-24

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424317, A61K 3119, A61K 3120

Patent

active

040256499

ABSTRACT:
Acetic acid derivatives of the formula: ##STR1## and pharmaceutically acceptable alkali metal salts thereof, wherein R represents the radical ##STR2## in which R.sub.1 and R.sub.2, which may be the same or different, each represent an alkyl radical having from 1 to 4 carbon atoms, R.sub.3 represents a hydrogen atom or a methyl radical and n is an integer in the range of from 0 to 3 inclusive.
They possess a competitive inhibitory activity with respect to .gamma.-aminobutyric .alpha.-ketoglutaric transaminase as well as antianoxic and anticonvulsant properties and they are useful for treating central neurological disorders whether resulting or not from cerebral ischemia.

REFERENCES:
patent: 2484486 (1949-10-01), Caldwell
patent: 2484500 (1949-10-01), Hagemeyer

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