Synthesis of 2'-deoxypyrimidine nucleosides

Details Synthesis of 2'-deoxypyrimidine nucleosides Synthesis of 2'-deoxypyrimidine nucleosides

1990-01-19

1993-04-06

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536124, 536 284, 536 282, 536 285, C07H 100

Patent

active

052005143

ABSTRACT:
A method for the preparation of 2'-deoxynucleosides and 2',3'-dideoxy-2',3'-didehydronucleosides that includes the step of reacting a nucleoside having hydroxyl groups in the 2' and 3' positions with a mixture of acyl bromide or chloride and HX, wherein X is Br or Cl, at moderate temperature, to give a haloacyl nucleoside derivative that can be deprotected and reduced to form the desired compound.

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