Thiazole derivatives of benzoic and phenylalkanoic acids

Details Thiazole derivatives of benzoic and phenylalkanoic acids Thiazole derivatives of benzoic and phenylalkanoic acids

1975-07-16

1977-05-24

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260302R, 260302S, 260299, 424270, C07D27754, C07D27736, C07D27734

Patent

active

040255280

ABSTRACT:
Thiazole derivatives represented by the general formula: ##STR1## wherein A is oxygen, sulfur, imino, or NR.sub.3, wherein R.sub.3 is C.sub.1.sub.-5 alkyl, C.sub.2.sub.-5 alkenyl, C.sub.3.sub.-5 alkynyl, C.sub.3.sub.-6 cycloalkyl-C.sub.1.sub.-3 alkyl or C.sub.7.sub.-8 aralkyl; R.sub.1 is hydrogen, C.sub.1.sub.-5 alkyl, C.sub.2.sub.-5 alkenyl, C.sub.3.sub.-5 alkynyl, C.sub.3.sub.-6 cycloalkyl-C.sub.1.sub.-3 alkyl or C.sub.7.sub.- 8 aralkyl; R.sub.2 is hydroxy, C.sub.1.sub.-5 alkoxy or OM, wherein M is alkali metal, or one equivalent of alkaline earth metal, cupric or aluminum cation; n is an integer of 0 or 1; X.sub.1 and X.sub.2 are independently hydrogen or C.sub.1.sub.-5 alkyl; Y.sub.1 and Y.sub.2 are independently hydrogen, halogen, C.sub.1.sub.-5 alkyl, C.sub.1.sub.-5 alkoxy or trifluoromethyl; and the group ##STR2## is linked to one of the meta or para positions of the benzene ring A, n is not 0 when A is imino and --CH.sub.2 --COR.sub.2 does not substitute the thiazole ring when A is imino, being useful as anti-inflammatory, anti-rheumatic, analgesic or anti-lipemia agents.

REFERENCES:
patent: 2863874 (1958-12-01), Gregory
patent: 3004033 (1961-10-01), D'Amico
patent: 3536727 (1970-10-01), Cavalla et al.
patent: 3840548 (1974-10-01), Malen et al.
patent: 3933838 (1976-01-01), Manghisi et al.
Mathes et al., Chemical Abstracts 47 12,355g (1953).
Pujari et al., Chemical Abstracts 49 10,267b (1955).
Das et al., Chemical Abstracts 49 11,626c (1955).
Mahapatra et al., Chemical Abstracts 75 104,845u (1971).
Rout et al., J. Am. Chem. Soc. 75 pp. 4057-4058 (1953).

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