Particulate biologically active reagent containing polyoxyalkyle

Details Particulate biologically active reagent containing polyoxyalkyle Particulate biologically active reagent containing polyoxyalkyle

1990-07-25

1993-04-06

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 435 75, 435 732, 435 734, 435 792, 435 793, 435 794, 435 795, 435962, 435969, 435970, 436523, 436528, 436531, 436535, 422 56, 422 57, 524817, 524825, 526286, 526293, 526320, 526346, C12Q 168, G01N 2100, C08L 3300, C08F 1216

Patent

active

052003159

ABSTRACT:
Biologically active reactive are prepared from particles of copolymers having polyoxyalkylene side chains, each of which side chains has a molecular weight of at least about 88. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through reactive groups on the particle surface. These reagents are used to advantage in analytical elements and methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents. Adsorption of undesirable proteins on the particles of the reagents was considerably reduced because of the specific composition of the particles.

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Napoka et al, CHEM AB97(2)11787, "Interactions between biological components and hydrogels with poly(oxyethylene) chain . . . " in Kobunshi Ronbunshu, 39(4), 165-71 (1982).
Andrade et al, CHEMAB 113(12)99914, "Polymer surfactants for protein resistance . . . " in WO9003406 Apr. 5, 1990.

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