Inhibitors of protein kinase C activity as protectors against se

Details Inhibitors of protein kinase C activity as protectors against se Inhibitors of protein kinase C activity as protectors against se

1991-08-21

1993-04-06

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514727, 514738, 514739, 514921, A01N 4304, A01N 3318, A01N 3100

Patent

active

H00011681

ABSTRACT:
An agent and treatment for a subject susceptible to septic shock. The subject is treated with a PKC inhibitor, preferably wit a PKC inhibitor selected from the group consisting of lipid analogues. Preferred among the lipid analogues are sphingosine and its analogues. The inhibitors of this invention are administered, preferably by infusion in a suitable pharmaceutical carrier, in a range of 0.1 to 50 mg/Kg body weight preferably in the range of 0.5 to 25 mg/Kg body weight and most preferably in the range of 1 to 5 mg/Kg body weight.

REFERENCES:
patent: 4816450 (1989-03-01), Bell
patent: 5010059 (1991-04-01), Schmidt
Hannun & Bell, Science, vol. 243, pp. 500-506, (Jan. 1989).
Merrill & Stevens, Biochimica & Biophysica Acta, vol. 1010, pp. 131-139 (9).
Igarashi et al., Biochemistry, vol. 28, pp. 6796-6800, (1989).
Merrill et al., Biochemistry, vol. 28, pp. 3138-3145, (1989).

Affiliated with

Also associated with

Rating

Inhibitors of protein kinase C activity as protectors against se does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of protein kinase C activity as protectors against se, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of protein kinase C activity as protectors against se will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-527251