Process for preparing .alpha.-hydroxyaldehyde

Details Process for preparing .alpha.-hydroxyaldehyde Process for preparing .alpha.-hydroxyaldehyde

1981-04-27

1983-05-10

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568483, 556436, C07C 4556

Patent

active

043831222

ABSTRACT:
An optically active or racemic .alpha.-hydroxyaldehyde represented by the general formula (2), ##STR1## wherein R.sub.1 represents a C.sub.6 -C.sub.14 aryl group, C.sub.1 -C.sub.10 alkyl group, C.sub.3 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R.sub.2 represents a C.sub.1 -C.sub.10 alkyl group, C.sub.2 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.14 aryl group, or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals, and prepared by allowing an optically active or racemic compound represented by the general formula (1), ##STR2## (wherein A represents a C.sub.6 -C.sub.14 aryl group or a C.sub.1 -C.sub.4 alkyl or alkoxy group- or halogen-substituted C.sub.6 -C.sub.14 aryl group and R.sub.1 is as defined above) to react with a Grignard reagent, and thereafter hydrolyzing the reaction product.

REFERENCES:
patent: 4131623 (1978-12-01), Meyers
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Eliel et al., Jour. Amer. Chem. Soc., vol. 100, No. 5, Mar. 1978, 1614-1616.
Mukaiyama et al., Chemistry Letters, Nov. 1978, 1253-1256.
Beilsteins Handbuch der Organischen Chemie, 4th Ed., 3rd Sup., vol. 8, part 2, (1969), Formula III, p. 1367.
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