Sulfonyl or carbonyl inositol derivatives useful as anti-inflamm

Details Sulfonyl or carbonyl inositol derivatives useful as anti-inflamm Sulfonyl or carbonyl inositol derivatives useful as anti-inflamm

1982-05-10

1984-10-02

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424301, 424303, 424304, 424305, 424308, 424309, 424310, 424311, 424312, 424313, 424314, 424320, 424321, 424322, 424324, 260404, 260408, 260410, 260413, 260455B, 260456R, 260456A, 260456P, 260457, 260464, 260465D, 260928, 260938, 260944, 260456F, 560 9, 560 18, 560 20, 560 22, 560 28, 560 29, 560 31, 560 32, 560 41, 560 47, 560 49, 560 50, 560 55, 560 56, 560 64, 670 65, 560 72, 560 75, 560100, 560104, 560105, 560106, 560115, 560125, 560126, 560128, 560148, 560149, 560160, 560161, 560162, 560173, 560183, 56

Patent

active

044748060

ABSTRACT:
Sulfonyl or carbonyl derivatives of inositols are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These inositol derivatives are prepared by condensation of a protected inositol with a substituted sulfonic or carboxylic acid derivative followed by removal of protecting groups.

REFERENCES:
patent: 2997490 (1959-05-01), Huber
patent: 2997491 (1959-09-01), Huber
patent: 3207780 (1965-09-01), Argoudelis
patent: 3470295 (1969-09-01), Revici
patent: 4033971 (1977-07-01), Hauck
Wilson, "Textbook of Organic Medical and Pharmaceutical Chemistry," pp. 39-40, (1954).
Roche, "Design of Biopharmaceutical Properties Through Prodrugs and Analogs," pp. 281-285, 299-304 & 311-315, (1977).
Dewert Abst. of Jap. Pat. 48-49743.

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