Enkephalinase inhibitors

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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A61K 31415

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active

044747950

ABSTRACT:
The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##

REFERENCES:
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4235885 (1980-11-01), Sundeen et al.
patent: 4254107 (1983-03-01), Veber et al.
patent: 4329495 (1982-05-01), Bindra
Roques et al., "The Enkephalinase Inhibitor Thiorphan . . . ", Nature, vol. 288, Nov. 1980, pp. 286-288.
Hughes et al., "Identification of Two Related Pentapeptides . . . ", Nature, vol. 258, Dec. 1975, pp. 577-579.
Malfroy et al., "High Affinity Enkephalin . . . ", Nature, vol. 276, Nov. 1978, pp. 523-526.
Patey et al., "Selective Protection of Methionine Enkephalin . . . ", Science, vol. 212, Jun. 1981, pp. 1153-1155.

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