Process for the production of human luteinizing hormone

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide

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435 68, 435 71, C12P 2102, C12P 2104, C12P 2100

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043830358

ABSTRACT:
The present invention relates to a process for the production of human luteinizing hormone (hLH).
More precisely, the invention relates to a process for the mass production of hLH, comprising in vivo multiplication of human cells capable of producing hLH, using non-human warm-blooded animal, and exposure of the multiplied human cells to a luteinizing hormone inducer.
The hLH production according to the invention is extremely higher, in terms of hLH production per cell, than that attained by conventional processes using in vitro tissue culture, thus, hLH can be used in a sufficient amount in the prevention and treatment of human diseases.

REFERENCES:
patent: 4276282 (1981-06-01), Sugimoto et al.
patent: 4285929 (1981-08-01), Sugimoto et al.
patent: 4288546 (1981-09-01), Narasimhan et al.
patent: 4328207 (1982-05-01), Sugimoto
Chemical Abstracts, 91:86930s (1979).

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