Cyclopropylmethyl piperazines, the process for preparing the sam

Details Cyclopropylmethyl piperazines, the process for preparing the sam Cyclopropylmethyl piperazines, the process for preparing the sam

1981-09-25

1984-10-02

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544121, 544358, 544359, 544360, 544372, 544376, 544377, 544386, 544391, 544392, 544399, 544401, 4242484, C07D24104, C07D29500, A61K 31495

Patent

active

044747837

ABSTRACT:
A compound having the formula ##STR1## in which R is hydrogen or alkyl having 1 to 4 carbon atoms; R.sub.1 is hydrogen, alkyl having 1 to 5 carbon atoms, cycloalkylmethyl in which the cycloalkyl group has from 3 to 6 carbon atoms, 2-hydroxyethyl, alkoxycarbonyl in which the alkoxy group has 1 or 2 carbon atoms, 2-carboxypropyl, N-benzyl-2-carbamoyl propyl, phenyl, phenyl substituted by methoxy, trifluoromethyl or acetyl, benzyl, benzyl substituted by halogen, benzoyl, benzoyl substituted by three methoxy groups, 3,5-dimethoxy-4-acetoxy or 3,5-dimethoxy-4-ethoxycarbonyloxy, cinnamoyl, cinnamoyl in which the phenyl ring is substituted with trifluoromethyl or by one or more methoxy groups, phenoxyacetyl, phenoxyacetyl in which the phenyl ring is substituted with halogen or methoxy, and ##STR2## in which m is 2 or 3 and R.sub.2 and R.sub.3 are identical and are alkyls having 1 to 3 carbon atoms; A is a pharmaceutically acceptable compound selected from the group consisting of inorganic acids, organic acids, alkyl halides and aryl halides; and n is 0, 1, 2 or 3;
The compounds are useful in the treatment of cardiac disease symptomized by low cardiac flow.

REFERENCES:
patent: 2724713 (1955-11-01), Goldman et al.
patent: 4057413 (1977-11-01), Naumann et al.
patent: 4096261 (1978-06-01), Horrom et al.
patent: 4163849 (1979-08-01), Lumma, Jr. et al.
Irwin et al., "Journal of Med. Chem.", vol. 15, No. 6, pp. 690-692, (1972), Alkyl Derivatives of Tetrahydrousoquinololine, 1-Phenylpiperazine and 4-Dyphenylmethylpiperidine.

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