Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1982-07-16
1984-10-02
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
260239A, 260239B, 544 2, 544 3, 544 63, 548120, 549 13, A61K 4300, A61K 4900
Patent
active
044747462
ABSTRACT:
A radiopharmaceutical chemical compound comprising a radioactive isotope, other than an isotope of iodine, in chemical combination with at least one amine group. The compound has a lipophilicity sufficiently high at a pH of 7.6 to permit passage of the compound from the blood of a mammal into a target organ or tissue and sufficiently low at a pH of 6.6 to prevent rapid return of the compound from the target organ or tissue to the blood. The compound has a percent protein binding of less than ninety percent.
A method for selectively depositing a radiopharmaceutical compound in at least one target tissue or organ of a mammal, which tissue or organ has a significantly different intracellular pH than the blood of the mammal, by introducing the compound of the invention into the bloodstream of the mammal.
REFERENCES:
patent: 3759935 (1973-09-01), De Cat et al.
patent: 4031198 (1977-06-01), Jackson et al.
patent: 4279887 (1971-07-01), Baldwin et al.
patent: 4363793 (1982-12-01), Blau et al.
Blau Monte
Kung Hank F.
Crossetta, Jr. William J.
Dunn Michael L.
Nucker Christine M.
State University of New York
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