Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-02-08
1998-05-05
Ketter, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 536 241, 536 253, C12Q 168, G01N 3353, C07H 2100
Patent
active
057472530
ABSTRACT:
Methods useful for the determination of oligomers which have specific activity for a transcription factor or other target molecule from a pool of primarily randomly assembled subunits are provided. The disclosed methods involve repeated syntheses of increasingly simplified sets of oligomers coupled with novel selection procedures for determining oligomers having the highest activity. Freedom from the use of enzymes allows the application of these methods to any molecules which can be oligomerized in a controlled fashion.
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Davis Pete
Ecker David J.
Vickers Tim
Brusca John S.
ISIS Pharmaceuticals Inc.
Ketter James
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