Cyanoprostaglandins

Details Cyanoprostaglandins Cyanoprostaglandins

1977-04-25

1978-02-14

Curtis, Allen B.

Harness for working animal

542426, 542447, C07C17700, C07D30910

Patent

active

040740447

ABSTRACT:
The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, are bronchodilatory agents, useful in the treatment of bronchial asthma, bronchitis, pneumonia and emphysema. The 19-cyano-20-nor derivatives of prostaglandins E.sub.1 and E.sub.2, and certain esters thereof, which also have protecting groups on the hydroxy groups at C-11 and C-15 are useful intermediates for the preparation of the bronchodilatory agents of this invention.

REFERENCES:
patent: 3723423 (1973-03-01), Anderson et al.
patent: 3853854 (1974-12-01), Weinshenker et al.
patent: 3870747 (1975-03-01), Wendler et al.
patent: 3923872 (1975-12-01), Caton et al.
J. Am. Chem. Soc. 90:12; 6/5/1968 -- "Total Synthesis of Prostaglandins . . ." pp. 3245-3247.

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