Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-02-11
1989-06-20
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544143, C07D41300, A61K 3140
Patent
active
048409502
ABSTRACT:
4-Arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles, useful as analgesic agents, are prepared by reaction of a 3-arylcarbonyl-2-methylnitrobenzene with DMF dimethyl acetal; reductive cyclization of the product with hydrogen over a catalyst; and N-alkylation of the resulting 4-arylcarbonylindole with an appropriate 4-(halo-lower-alkyl)morpholine in the presence of a strong base.
REFERENCES:
patent: 3182071 (1965-05-01), Shavel et al.
patent: 3215699 (1965-11-01), Shavel et al.
patent: 3946029 (1976-03-01), Deschamps et al.
patent: 4581354 (1986-04-01), Bell
Croce, Ann. di Chim., 63, 29-35 (1973).
Bell Malcolm R.
D'Ambra Thomas E.
Covington Raymond
DuPont Paul E.
Hollrah Glennon H.
Sterling Drug Inc.
Webb William G.
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