High temperature method for the production of ribavirin

Details High temperature method for the production of ribavirin High temperature method for the production of ribavirin

1987-09-17

1989-06-20

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 85, 435840, C12P 1938, C12P 1928, C12R 113

Patent

active

048408980

ABSTRACT:
A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine and the temperature during at least a part of the reaction is at or above 65.degree. C. The method is capable of high production rates and high concentrations of the final product.

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U.S. Ser. No. 97,767, filed 9/17/87, Pochodylo.

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