Mice and cells with a homozygous disruption in the RNase L gene

Details Mice and cells with a homozygous disruption in the RNase L gene Mice and cells with a homozygous disruption in the RNase L gene

1997-10-03

2000-02-22

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 3, 800 21, 435325, 4353201, 435455, 536 231, C12N 1511, C12N 1585, A01K 6700, G01N 3300

Patent

active

060282436

ABSTRACT:
The present invention provides a mutant, non-human mammal, particularly a mutant mouse, having a homozygous disruption in the RNase L gene thereof. Since the homozygous disruption in the RNase L gene leads to minimal if any production of RNase L in the mutant mammals, such mutant mammals are useful for assessing the effect of antiviral drugs on the induction, synthesis, or activation of RNase L. The present invention also relates to mutant, non-human, embryonic stem cell lines having a heterozygous disruption of the RNase L gene thereof, to isolated mammalian cells having a homozygous disruption in the RNase L gene thereof, and to a DNA construct comprising a DNA sequence of a disrupted coding exon of a RNase L gene.

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