Process for producing 2-amino-4,6-dichloropyrimidine

Details Process for producing 2-amino-4,6-dichloropyrimidine Process for producing 2-amino-4,6-dichloropyrimidine

1989-01-31

1990-05-29

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544243, C07D23942, C07F 965

Patent

active

049297295

ABSTRACT:
The present invention relates to an industrially advantageous process for producing 2-amino-4,6-dichloropyrimidine, which comprises reacting 2-amino-4,6-dihydroxypyrimidine or its salt with phosphorus oxychloride at a temperature of from 50.degree. to 100.degree. C. in the presence of a solvent and an acid removing agent. Further, the yield of 2-amino-4,6-dichloropyrimidine can be improved by hydrolyzing 4,6-dichloro-2-pyrimidinylphosphoramidic dichloride produced as a by-product of the chlorination reaction to form 2-amino-4,6-dichloropyrimidine. The 2-amino-4,6-dichloropyrimidine produced by the process of the present invention is useful as an intermediate for medicines and agricultural chemicals.

REFERENCES:
patent: 3991190 (1976-11-01), Garzia et al.
Chem. Berichte, vol. 36, No. 1 (1903), p. 2229.
The Journal of the American Chemical Society, vol. 73, pp. 3011-3012 (1951) in p. 3012 (Langerman et al.).
The Chemistry of Heterocyclic Compounds "Pyrimidines", (D. J. Brown) pp. 162-164 (1962).

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