Chemokine .beta.-6 antagonists

Details Chemokine .beta.-6 antagonists Chemokine .beta.-6 antagonists

1997-12-19

2000-02-22

Kemmerer, Elizabeth

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530397, 530399, C07K 14435, C07K 1452

Patent

active

060281693

ABSTRACT:
Human chemokine .beta.-6 agonist and antagonist polypeptides and DNA encoding such polypeptides and procedure for producing such polypeptides by recombinant technique are disclosed. The chemokine .beta.-6 antagonists of the present invention may be employed to treat rheumatoid arthritis, lung inflammation, allergy, asmtha, infectious diseases and to prevent inflammation and atherosclerosis. The chemokine .beta.-6 agonists may be employed to myeloprotect patients undergoing chemotherapy.

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