Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-10-30
2000-02-22
Stockton, Laura L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514359, 514376, 548100, 548183, 548226, A61K 3142, A61K 31425, C07D41312, C07D41712
Patent
active
060280883
ABSTRACT:
The present invention provides thiazolidinediones which are useful as antiproliferative, antiinflammatory and antiinfective agents. These compounds are useful for the treatment of certain endocrine diseases including diabetes, certain malignant and non-malignant proliferative diseases including prostate cancer, breast cancer, psoriasis, and acne, certain cardiovascular disorders including hypertension and occlusive vascular diseases.
REFERENCES:
patent: 3450717 (1969-06-01), Kramer et al.
patent: 3878191 (1975-04-01), Fukumoto et al.
patent: 4079139 (1978-03-01), Gay
patent: 4572912 (1986-02-01), Yoshioka et al.
patent: 4697020 (1987-09-01), Storni et al.
patent: 4841077 (1989-06-01), Ito et al.
patent: 4886806 (1989-12-01), Walenta et al.
patent: 4889941 (1989-12-01), Wu et al.
patent: 4970301 (1990-11-01), Rolland et al.
patent: 5012852 (1991-05-01), Walenta et al.
patent: 5120754 (1992-06-01), Clark et al.
patent: 5126129 (1992-06-01), Wiltrout et al.
patent: 5130379 (1992-07-01), Clark et al.
patent: 5143930 (1992-09-01), Yoshioka et al.
patent: 5280024 (1994-01-01), Bolland et al.
patent: 5338855 (1994-08-01), Yoshioka et al.
patent: 5431912 (1995-07-01), N'Guyen
patent: 5441971 (1995-08-01), Sohda et al.
patent: 5554519 (1996-09-01), Weber et al.
patent: 5594015 (1997-01-01), Kurtz et al.
patent: 5599826 (1997-02-01), Mertens et al.
Comrie, et al., "Some 2-iminoselenazolidin-4-ones and related compounds," J. Pharm. Pharmacol. 16:268-272 (1964).
Hulin, et al., "Novel thiazolidine-2,4-diones as potent euglycemic agents," J. Med. Chem. 35:1853-1864 (1992).
Lehmann, et al., "An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor .gamma. (PPAR.gamma.)" J. Biol. Chem. 270(22):12953-12956 (1995).
Wilson, et al., "The Structure--Activity relationship between peroxisome profliferator-activated receptor .gamma. agonism and the antihyperglycemic activity of thiazolidinediones," J. Med. Chem. 39:665-668 (1996).
Muller, et al., "Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice" (Abstract only) Proc. Natl. Acad. Sci. U.S.A. 95(15):8806-11 (Jul. 21, 1998).
Johnson, et al., "Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors," (Abstract only) J. Steroid Biochem. Mol. Biol. 63(1-3):1-8 (Sep.-Oct. 1997).
Avery Mitchell A.
Pershadsingh Harrihar A.
Stockton Laura L.
The University of Mississippi
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