Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-02-06
2000-02-22
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 530323, 530300, A61K 3800, A61K 3816
Patent
active
060280565
ABSTRACT:
The invention provides novel precursor reagents used in production of imaging agents derived from apcitide. Imaging agents made using the precursor reagents of the invention are useful for in vivo detection and diagnosis of thrombi. The precursor reagents of the invention may also be used in production of antithrombotic agents derived from apcitide.
REFERENCES:
patent: 5508020 (1996-04-01), Dean et al.
patent: 5645815 (1997-07-01), Dean et al.
Lister-James, et al., (1994) "A Structure-Activity-Relationship(SAR) Study of GPIIb/IIIa Receptor-Binding Peptides Radiolabeled with Tc-99m for Imaging Thromboembolism" Jnl. of Nucl. Med., 35, 257P (abstract).
Lister-James, et al., (1996) "Thrombus Imaging with a Technetium-99m-Labeled, Activated Platelet Receptor-Binding Peptide" Jnl. Nucl. Med., 37, 775-781.
Muto et al., (1995) "Detecting Deep Venous Thrombosis with Technetium-99m-Labeled Synthetic Peptide P280" Jnl. of Nucl. Med., 36, 1384-1391.
Pearson, et al., (1996) "Thrombus Imaging Using Technetium-99m-Labeled High-Potency GPIIb/IIIa Receptor Antagonists. Chemistry and Initial Biological Studies" Jnl. of Med. Chem., 39, 1372-1382.
Zheng, et al., (1997) "Synthesis and Characterization of 99Tc P246: A Technetium Peptide" American Chemical Society, Division of Inorganic Chemistry, 213th ACS National Meeting, 336.
Dean Richard T.
Lister-James John
Borin Michael
Diatide, Inc.
McDaniels Patricia A.
Tsang Cecilia
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