Compositions comprising the Tbp2 subunit of the transferrin rece

Details Compositions comprising the Tbp2 subunit of the transferrin rece Compositions comprising the Tbp2 subunit of the transferrin rece

1995-05-23

2000-02-22

Teng, Sally P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530395, 4242501, 435 691, 536 237, C07K 14705, A61K 3800

Patent

active

060280492

ABSTRACT:
The subject of the present invention is a DNA fragment which encodes a protein capable of being recognised by an antiserum against the transferrin receptor of the strain IM2394 or IM2169 of N. meningitidis as well as a process for producing the said protein by a recombinant route. By way of example, such a DNA fragment encodes the tbp1 subunit of the strain IM2394 or IM2169 or the tbp2 subunit of the strain IM2394 or IM2169.

REFERENCES:
patent: 5141743 (1992-08-01), Schryvers
patent: 5618541 (1997-04-01), Quentin-Millet
P. Stevenson et al, "Common Antigenic Domains in Transferrin-Binding-Protein 2 of Neisseria meningitidis, Neisseria gonorrhoeae, and Haemophilus influenzae Type b", Jun. 1992, Infection and Immunity, vol. 60, No. 6, pp. 2391-2396.
Schryvers et al., "Comparative Analysis of the Transferrin and Lactoferrin Binding Proteins in the Family Neisseriaceae", 1988, Molecular Microbiology, vol. 2, p. 281.
Schryvers et al., "Identification and Characterization of the Transferrin Receptor from Neisseria meningitidis", 1989, Can. J. of Microbiology, vol. 35, p. 409.
Cornelissen et al, "Gonococcal Transferrin-Binding Protein 1 is Required for Transferrin Utilization and Is Homologous to TonB-Dependent Outer Membrane Receptors", Sep. 1992, Journal of Bacteriology pp. 5788-5797.
Legrain et al, "Cloning and Characterization of Neisseria Meningitidis Genes Encoding the Transferrin-Binding Proteins Tbp1 and Tbp2", 1993, Gene, vol. 130, pp. 73-80.

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