Indole-7-carboxamide derivatives

Details Indole-7-carboxamide derivatives Indole-7-carboxamide derivatives

1992-11-24

1994-07-19

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514414, 514415, 514419, 544373, 544295, 548467, 548490, 548491, 548492, 548510, A61K 31495, A61K 3140, C07D40300, C07D20904

Patent

active

053309863

ABSTRACT:
This invention relates to indole-7-carboxamide derivatives of the formula ##STR1## where R.sub.1 through R.sub.6 are independently H, loweralkyl, aryl, and aralkyl; and in addition R.sub.3 and R.sub.5 can be joined together to form a piperazine ring of the formula ##STR2## where R.sub.7 is H, loweralkyl, aryl, arylloweralkyl, pyrimidyl; and R.sub.4 and R.sub.5 can be joined together to form a pyrrolidine ring of the formula ##STR3## where R.sub.8 is H, loweralkyl, aryl, arylloweralkyl; X is H, loweralkyl, halogen, NO.sub.2, CF.sub.3, NH.sub.2, and OR.sub.9 ; where R.sub.9 is loweralkyl, arylloweralkyl and n is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and the optical isomers thereof where such isomers exist.

REFERENCES:
patent: 4737501 (1988-04-01), Tominago et al.
patent: 5084455 (1992-01-01), Clemence et al.
patent: 5124332 (1992-06-01), Wise et al.
Romero et al, CA 116-21074f (1991).
Azria et al, CA 110-8041z (1988).
Palmer et al. CA 108-142835y (1988).
Asselin et al., J. Med. Chem., 29, 1009-1015 (1986).
Arzneim-Forsch/Drug Res., 39(I), No. 2, 187 (1989).

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