Method for immunological determination of hemoglobin derivative

Details Method for immunological determination of hemoglobin derivative Method for immunological determination of hemoglobin derivative

1996-12-16

2000-02-22

Housel, James C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436 66, 436 67, 436177, 436536, 436539, 436815, 530829, 530418, 530424, G01N 3353, G01N 3372, G01N 118, G01N 33539

Patent

active

060279079

ABSTRACT:
A hemoglobin derivative-containing sample is treated with a treating reagent containing 2-butanol and then immunologically analyzed to determine the quantity of the hemoglobin derivative. By the treatment with 2-butanol, the immunological determination for the hemoglobin derivative, particularly HbA.sub.1c, can be attained with high sensitivity by a simple procedure. Since 2-butanol-containing treating reagent does not affect the enzymatic activity, the homogeneous enzyme immunoassay with high sensitivity is realized.

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Carvalli et al. Acta Technologiae et Legis Medicamenti 7(2):101-111, 1996 (Abstract).
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Sigma Chemical Co. 1987, (Price List).
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Alcohol & Alcoholism Suppl. 1987; pp. 283-287--Y.M. Ostrovsky, et al. Interaction of Ethanol with Blood Protein.

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